Name | 3-(4-Fluorophenoxy)propionic acid |
Synonyms | RARECHEM AL BO 1453 IFLAB-BB F1924-0040 3-(4-FLUOROPHENOXY)PROPANOIC ACID 3-(4-FLUOROPHENOXY)PROPIONIC ACID 3-(4-Fluorophenoxy)propionic acid 3-(4'-FLUOROPHENOXY)PROPIONIC ACID |
CAS | 1579-78-8 |
EINECS | 216-424-6 |
Molecular Formula | C9H9FO3 |
Molar Mass | 184.16 |
Density | 1.267±0.06 g/cm3(Predicted) |
Melting Point | 83-85 °C (lit.) |
Boling Point | 170-175 °C(Press: 55-60 Torr) |
pKa | 4.82±0.10(Predicted) |
Physical and Chemical Properties | White crystal. The melting point is 84-86 ℃. |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
Hazard Note | Corrosive |
Hazard Class | IRRITANT |
Application | 3-(4-fluorophenoxy) propionic acid, also known as P-fluorophenoxy propionic acid, is a pharmaceutical intermediate. It has been reported in the literature that it can be used to prepare 4-chromanone compounds. |
preparation | in a 150mL three-necked flask with magnetic stirrer, thermometer, and reflux condenser, add 5.6g(0.05mol) A solution of p-fluorophenol, 0.05g (6.5 mol) potassium hydroxide and 25ml of water, which was stirred at room temperature for 15min. Then 0.06g (mol) of 3-chloropropionic acid, A mixed solution of 8.3g(0.06mol) potassium carbonate and 38ml water (about 30min drops), then add 0.4g(2.5mmol) potassium iodide and 0.5g(1.25mmol) polyethylene glycol PEG-400. After heating to reflux for 3H, the solution was cooled and acidified to pH = 1 by dropwise addition of concentrated hydrochloric acid under stirring. The solution was separated into layers, and solid precipitated after cooling with ice water, filtered, and recrystallized with water to obtain 1.9g of white flaky crystals in a yield of 25%. |
Use | an intermediate of sobier. |
production method | is prepared by reacting p-fluorophenol with β-chloropropionic acid. |